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Oud 07-03-2007   #1
isdatzo
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Standaard Eerste wetenschappelijke site over supplementen!

De volgende site geeft een overzicht van verschillende supplementen. Er wordt verteld wat er voor bewezen werking is en hoe sterk de bewijslast hiervoor is:

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Een paar concrete voorbeelden:

Chondroitin sulfate
De bewijslast hiervoor is Grade A: Strong scientific evidence for this use.
Multiple clinical trials have examined the use of oral chondroitin in patients with osteoarthritis of the knee and other locations (spine, hips, finger joints). Most of these studies have reported significant benefits in terms of symptoms (such as pain), function (such as mobility), and reduced medication requirements (such as anti-inflammatories). Despite these weaknesses and potential for bias in the available results, the weight of scientific evidence points to a beneficial effect when chondroitin is used for 6-24 months. Longer-term effects are not clear. Preliminary studies of topical chondroitin have also been conducted.Chondroitin is frequently used with glucosamine. Glucosamine has independently been demonstrated to benefit patients with osteoarthritis (particularly of the knee). It remains unclear if there is added benefit of using these two agents together compared to using either alone.

Creatine
De bewijslast voor beide punten is Grade C: Unclear scientific evidence for this use.
a)It has been suggested that creatine may help improve athletic performance or endurance by increasing time to fatigue (possibly by shortening muscle recovery periods). However, the results of research evaluating this claim are mixed. Findings from different studies disagree with each other, and most studies do not support the use of creatine to enhance sustained aerobic activities.
b)Multiple studies suggest that creatine may improve muscle mass and strength in men and women, particularly when accompanied by increased physical activity. However, studies of creatine in athletes have disagreed with each other. Although many experts believe that creatine may be useful for high-intensity, short-duration exercise, it has not been demonstrated effective in endurance sports. Benefit may be greatest when levels of creatine prior to supplementation are low, and in specific sub-populations such as older men.

DHEA
De bewijslast voor alle 3 de punten is Grade B: Good scientific evidence for this use.
a)Several studies suggest that DHEA may improve well-being, quality of life, exercise capacity, sex drive, and hormone levels in people with insufficient adrenal function (Addison's disease). Though promising, additional study is needed to make a strong recommendation. Adrenal insufficiency is a serious medical condition and should be treated under the supervision of a qualified health care professional, including a pharmacist.
b)The majority of clinical trials investigating the effect of DHEA on depression support its use for this purpose under the guidance of specialist. Further research is needed to confirm these results.
c)The majority of clinical trials investigating the effect of DHEA on weight or fat loss support its use for this purpose. Further research is needed to confirm these results.

Echinacea
De bewijslast voor alle 3 de punten is Grade C: Unclear scientific evidence for this use.
a)Echinacea has been studied alone and in combination preparations for immune system stimulation (including in patients receiving cancer chemotherapy). It remains unclear if there are clinically significant benefits. Additional studies are needed in this area before conclusions can be drawn regarding safety or effectiveness.
b)Preliminary studies suggest that echinacea is not helpful for preventing the common cold in adults. A recent meta-analysis suggested that standardized extracts of echinacea were effective in the prevention of symptoms of the common cold after clinical inoculation, compared with placebo. In children, a combination of echinacea, propolis, and vitamin C has been reported to reduce the number and duration of cold episodes. However, prevention research overall has not been well designed, and additional trials are needed before a clear conclusion can be drawn.
c)Although multiple low quality studies have previously suggested that taking echinacea by mouth by adults when cold symptoms begin may reduce the length and severity of symptoms, a clinical trial reported in July 2005 did not demonstrate any clinical benefit. Recent meta-analyses are conflicting; one suggested that standardized extracts of echinacea were effective in the prevention of symptoms of the common cold after clinical inoculation, compared with placebo, whereas the other reported no such benefit. Further research is needed.

Ephedra
De bewijslast hiervoor is Grade A: Strong scientific evidence for this use.
Ephedra contains the chemical ephedrine, which appears to cause weight loss when used in combination with caffeine, based on the available scientific evidence. The results of research on ephedrine alone without caffeine are unclear. The amounts of ephedrine in commercially available products has widely varied.

Flaxseed and flaxseed oil
De bewijslast hiervoor is Grade C: Unclear scientific evidence for this use.
a)People who have had a heart attack are reported to benefit from diets rich in alpha-linolenic acid, which is found in flaxseed. Good studies that examine the effect of flaxseed on heart disease in humans are not available. It is unclear whether flaxseed supplementation alters the course of heart disease.

Glucosamine
De bewijslast hiervoor is Grade B: Good scientific evidence for this use.
Several human studies and animal experiments report benefits of glucosamine in treating osteoarthritis of various joints of the body, although the evidence is less plentiful than that for knee osteoarthritis. Some of these benefits include pain relief, possibly due to an anti-inflammatory effect of glucosamine, and improved joint function. Overall, these studies have not been well designed. Although there is some promising research, more study is needed in this area before a firm conclusion can be made.

Green tea
De bewijslast voor alle 3 de punten is Grade C: Unclear scientific evidence for this use.
a)Overall, the relationship of green tea consumption and human cancer remains inconclusive. Evidence from well-designed clinical trials is needed before a firm recommendation can be made in this area.
b)There is early suggestive evidence that regular intake of green tea may reduce the risk of heart attack or atherosclerosis (clogged arteries). Further well-designed clinical trials are needed before a recommendation can be made in this area.
c)There are several small human studies addressing the use of green tea extract (GTE) capsules for weight loss or weight maintenance in overweight or average weight individuals. Study results are mixed. Better research is needed before a recommendation can be made in this area.

Milk thistle (Silybum marianum)
De bewijslast voor de eerste 2 punten is Grade B: Good scientific evidence for this use. Voor het 3e punt is dit Grade C: Unclear scientific evidence for this use.
a)Several studies of oral milk thistle for hepatitis caused by viruses or alcohol report improvements in liver tests. However, most studies have been small and poorly designed. More research is needed before a recommendation can be made.
b)Multiple studies from Europe suggest benefits of oral milk thistle for cirrhosis. In experiments up to five years long, milk thistle has improved liver function and decreased the number of deaths that occur in cirrhotic patients. Although these results are promising, most studies have been poorly designed. Better research is necessary before a strong recommendation can be made.
c)Several studies suggest possible benefits of milk thistle to treat or prevent liver damage caused by drugs or toxic chemicals. Results of this research are not clear, and most studies have been poorly designed. Therefore, there is not enough scientific evidence to recommend milk thistle for this use.

Omega-3 fatty acids, fish oil, alpha-linolenic acid
De bewijslast voor het eerste punt is Grade A: Strong scientific evidence for this use. Voor het 2e punt is Grade B: Good scientific evidence for this use.
a)Several well-conducted randomized controlled trials report that in people with a history of heart attack, regular consumption of oily fish or fish oil/omega-3 supplements reduces the risk of non-fatal heart attack, fatal heart attack, sudden death, and all-cause mortality (death due to any cause). Most patients in these studies were also using conventional heart drugs, suggesting that the benefits of fish oils may add to the effects of other therapies.
b)Several large studies of populations ("epidemiologic" studies) report a significantly lower rate of death from heart disease in men and women who regularly eat fish. Other epidemiologic research reports no such benefits. It is not clear if reported benefits only occur in certain groups of people, such as those at risk of developing heart disease. Overall, the evidence suggests benefits of regular consumption of fish oil. However, well-designed randomized controlled trials which classify people by their risk of developing heart disease are necessary before a firm conclusion can be drawn

Saw palmetto
De bewijslast hiervoor is Grade A: Strong scientific evidence for this use.
Numerous human trials report that saw palmetto improves symptoms of benign prostatic hypertrophy (BPH) such as nighttime urination, urinary flow, and overall quality of life, although it may not greatly reduce the size of the prostate. The effectiveness may be similar to the medication finasteride (Proscar®) with fewer side effects. Although the quality of these studies has been variable, overall they suggest effectiveness.

St. John's wort (St. Janskruid)
De bewijslast hiervoor is Grade A: Strong scientific evidence for this use.
St. John's wort has been extensively studied in Europe over the last two decades, with more recent research in the United States. Short-term studies (1-3 months) suggest that St. John's wort is more effective than placebo (sugar pill), and equally effective as tricyclic antidepressants (TCAs) in the treatment of mild-to-moderate major depression. Comparisons to the more commonly prescribed selective serotonin reuptake inhibitor (SSRI) antidepressants, such as fluoxetine (Prozac®) or sertraline (Zoloft®), are more limited. However, other data suggest that St. John's wort may be just as effective as SSRIs with fewer side effects. Safety concerns exist as with most conventional and complementary therapies.



Let op:
Ik heb alleen de bewijslast gepost voor deze supplementen in relatie tot de lichamelijke effecten die hierboven zijn vernoemd. In relatie tot andere aspecten van de gezondheid veroorzaken deze supplementen weer andere reacties. Controleer dus zelf altijd wat dit supplement verder doet door op de site te kijken!
isdatzo is offline   Met citaat antwoorden
De Volgende 4 Gebruikers Zeggen Bedankt isdatzo Voor Deze Bruikbare Informatie.
Drerappoima (10-17-2011), Exhichmitkk (10-09-2011), taksslart (01-08-2013), thourgygors (12-12-2012)
Oud 07-07-2007   #2
the machine
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Standaard Re: Eerste wetenschappelijke site over supplementen!

Lijkt me wel interessant; zal het morgen eens bekijken!
Healthy nutrition can change your whole life!
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De Volgende 2 Gebruikers Zeggen Bedankt the machine Voor Deze Bruikbare Informatie.
Annabowaced (07-07-2018), Drerappoima (11-25-2011)
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